M54 then A5. Turn left just after Corwen on to the B4401 for 4 miles. After Llandrillo follow the road for 3.7 miles then turn left at the Bryntirion Inn; the gates to Palé Hall will then be seen 100m on the right.
Sat nav may guide you off the A5 at Knockin and along the Tanat valley. Beautiful, but narrow and mountainous, be aware this route might be best avoided at night or in poor weather.
Alternatively, if travelling from the South West you might enjoy the scenic route through the middle of Wales taking the A479 up from Abergavenny and then the A470 to Dolgellau, approaching Palé Hall from Bala.